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- Product Description
- Physical properties
- Product Advantages
- Application
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- Commodity name: MPPE-1
- 产品副标题: CAS:5855-13-4
Chinese name
4-Maleimidebenzoic acid
English name
4-MBA; p-Maleimidobenzoic acid
CAS
5855-13-4
Molecular formula
C 11 H 7 NO 4
Molecular weight
217.18
Product Applications:
Major category
Segmentation
Description
Biomarker
Protein and Antibody Labeling
Fluorescent dyes, biotin, enzymes, or other reporter molecules are conjugated to proteins or antibodies bearing free thiol groups via their carboxyl moieties. First, the carboxyl group of 4-MBA is activated with EDC/NHS to enable its reaction with the amino groups on the reporter molecule; subsequently, the resulting maleimide‑functionalized reporter molecule can specifically bind to the thiol groups on the protein.
Peptide (protein) cross-linking, complicating spatial conformation
It is used to link a molecule containing an amino group (such as a peptide or protein) with another molecule bearing a thiol group, enabling the study of intermolecular interactions or the assembly of complex biomolecular complexes.
Biosensor Preparation
In the construction of biosensors, it is used to immobilize biorecognition elements—such as antibodies or enzymes—on the sensor chip surface in a定向 manner, thereby preserving their biological activity.
Medicine
Antibody-Drug Conjugates (ADCs)
In the construction of ADCs, it can be used to conjugate cytotoxic drugs to monoclonal antibodies. Antibodies typically generate thiol groups by reducing their interchain disulfide bonds, enabling efficient and specific coupling with maleimide moieties.
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Material modification or functionalization
Maleimide-modified resin (via physical blending or chemical incorporation)
For example, bismaleimides are chemically modified with polyphenylene ether, aminoplasts, and other materials;
For example, copolymerization modification with allyl‑type compounds (allyl phenoxylates, allyl bisphenol A) and benzoxazine compounds.
Surface modification of the material, introducing maleimide groups.
Surface modification of amino-containing materials (such as amino-modified magnetic beads, chips, nanoparticles, etc.)
Product Introduction
|
Chinese name |
4-Maleimidebenzoic acid |
|
English name |
4-MBA; p-Maleimidobenzoic acid |
|
CAS |
5855-13-4 |
|
Molecular formula |
C 11 H 7 NO 4 |
|
Molecular weight |
217.18 |
Product Applications:
|
Major category |
Segmentation |
Description |
|
Biomarker |
Protein and Antibody Labeling |
Fluorescent dyes, biotin, enzymes, or other reporter molecules are conjugated to proteins or antibodies bearing free thiol groups via their carboxyl moieties. First, the carboxyl group of 4-MBA is activated with EDC/NHS to enable its reaction with the amino groups on the reporter molecule; subsequently, the resulting maleimide‑functionalized reporter molecule can specifically bind to the thiol groups on the protein. |
|
Peptide (protein) cross-linking, complicating spatial conformation |
It is used to link a molecule containing an amino group (such as a peptide or protein) with another molecule bearing a thiol group, enabling the study of intermolecular interactions or the assembly of complex biomolecular complexes. |
|
|
Biosensor Preparation
|
In the construction of biosensors, it is used to immobilize biorecognition elements—such as antibodies or enzymes—on the sensor chip surface in a定向 manner, thereby preserving their biological activity. |
|
Medicine |
Antibody-Drug Conjugates (ADCs) |
In the construction of ADCs, it can be used to conjugate cytotoxic drugs to monoclonal antibodies. Antibodies typically generate thiol groups by reducing their interchain disulfide bonds, enabling efficient and specific coupling with maleimide moieties. |
|
|
--- |
--- |
|
Material modification or functionalization |
Maleimide-modified resin (via physical blending or chemical incorporation) |
For example, bismaleimides are chemically modified with polyphenylene ether, aminoplasts, and other materials; For example, copolymerization modification with allyl‑type compounds (allyl phenoxylates, allyl bisphenol A) and benzoxazine compounds. |
|
|
Surface modification of the material, introducing maleimide groups. |
Surface modification of amino-containing materials (such as amino-modified magnetic beads, chips, nanoparticles, etc.) |
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